# Latest **URL:** https://forum.certara.com/latest.md?page=2 [Latest](https://forum.certara.com/latest.md) · [Categories](https://forum.certara.com/categories.md) · [Tags](https://forum.certara.com/tags.md) **Page:** 3 --- ## [NCA Results Plots](https://forum.certara.com/t/nca-results-plots/3698)
**Author:** [@beqool](https://forum.certara.com/u/beqool)\ **Replies:** 4\ **Last updated:** [January 28, 2026, 9:50pm UTC](https://forum.certara.com/t/nca-results-plots/3698 "2026-01-28T21:50:59Z")
Hello all! When doing an NCA in Phoenix WinNonlin the maximum number of plots shown under “Results\>\>Plots\>\>Observed Y and Predicted Y vs X” is 100. When sample size is large enough (N\>50 in a 2-period designs, N\>33 in 3… --- ## [ASSIGNING NATURAL KEY variables from SUPPQUAL](https://forum.certara.com/t/assigning-natural-key-variables-from-suppqual/1175)
**Author:** [@sara\_ks](https://forum.certara.com/u/sara_ks)\ **Replies:** 4\ **Last updated:** [January 26, 2026, 4:54pm UTC](https://forum.certara.com/t/assigning-natural-key-variables-from-suppqual/1175 "2026-01-26T16:54:30Z")
I don’t think there is a well-defined mechanism for this. The natural keys are assigned at the ItemGroupDef/ItemRef level, and the supplemental qualifier variables do not appear there. The reason is that SDTM and the F… --- ## [Phoenix's new licensing system with 8.5+ https://my.certara.net](https://forum.certara.com/t/phoenixs-new-licensing-system-with-8-5-https-my-certara-net/3748)
**Author:** [@SimonDavis](https://forum.certara.com/u/SimonDavis)\ **Replies:** 6\ **Last updated:** [January 22, 2026, 1:35pm UTC](https://forum.certara.com/t/phoenixs-new-licensing-system-with-8-5-https-my-certara-net/3748 "2026-01-22T13:35:55Z")
Hopefully you have now all seen announcements about Phoenix 8.5, a key part of this new release is Certara moving away from the old Sentinel licensing system, so no more activation codes ! Phoenix 8.5 and later versions… --- ## [Efficiently Calculating Cmax and AUC with 95% CI for 5th, 50th, and 95th Quartiles in Large Phoenix NLME Simulations](https://forum.certara.com/t/efficiently-calculating-cmax-and-auc-with-95-ci-for-5th-50th-and-95th-quartiles-in-large-phoenix-nlme-simulations/4357)
**Author:** [@Bhim\_Bahadur](https://forum.certara.com/u/Bhim_Bahadur)\ **Replies:** 5\ **Last updated:** [January 20, 2026, 9:00pm UTC](https://forum.certara.com/t/efficiently-calculating-cmax-and-auc-with-95-ci-for-5th-50th-and-95th-quartiles-in-large-phoenix-nlme-simulations/4357 "2026-01-20T21:00:43Z")
Hi Users and Experts, I used Phoenix NLME to simulate concentration–time (CT) profiles for 56 subjects with 1000 replicates each, over 672 hours with 1‑hour sampling. This produced a dataset of ~37 million rows. Phoenix… --- ## [Question regarding Parameter Freezing for Simulation: Should I fix both Fixed and Random Effects?](https://forum.certara.com/t/question-regarding-parameter-freezing-for-simulation-should-i-fix-both-fixed-and-random-effects/4353)
**Author:** [@Virunya\_Komenkul](https://forum.certara.com/u/Virunya_Komenkul)\ **Replies:** 2\ **Last updated:** [January 20, 2026, 7:48am UTC](https://forum.certara.com/t/question-regarding-parameter-freezing-for-simulation-should-i-fix-both-fixed-and-random-effects/4353 "2026-01-20T07:48:01Z")
Hi everyone, I am currently working on a simulation step using my final PK/PD model in Phoenix NLME. I have a question regarding the best practice for “freezing” parameters before running the simulation. When transitio… --- ## [Phoenix NLME simulation issue](https://forum.certara.com/t/phoenix-nlme-simulation-issue/4355)
**Author:** [@sylim](https://forum.certara.com/u/sylim)\ **Replies:** 6\ **Last updated:** [January 9, 2026, 8:48pm UTC](https://forum.certara.com/t/phoenix-nlme-simulation-issue/4355 "2026-01-09T20:48:01Z")
Hi, I added two simulation tables in Phoenix NLME. Table 01 uses continuous time points: seq(0,336,0.5), Table 02 uses specific time points at 310, 312, 314, etc. The simulated concentrations in Table 01 and Table 02 we… --- ## [ADaM PCSTRESU CT](https://forum.certara.com/t/adam-pcstresu-ct/4352)
**Author:** [@k-saku](https://forum.certara.com/u/k-saku)\ **Replies:** 4\ **Last updated:** [January 8, 2026, 7:04am UTC](https://forum.certara.com/t/adam-pcstresu-ct/4352 "2026-01-08T07:04:03Z")
ADPCにPCSTRESUを実装していますが、ADaMのdefineのバリデーションで、DD0118およびDD0028のIssueが表示されます。SDTM IG3.3に準拠して作成しているため、PCSTRESUのCTはPK UNITを定義しておりますが、それが原因でしょうか。Issueの解消方法などありますでしょうか。 --- ## [User defined Parameters](https://forum.certara.com/t/user-defined-parameters/4349)
**Author:** [@Kamel\_Moktefi](https://forum.certara.com/u/Kamel_Moktefi)\ **Replies:** 3\ **Last updated:** [January 7, 2026, 1:23pm UTC](https://forum.certara.com/t/user-defined-parameters/4349 "2026-01-07T13:23:21Z")
Hi, I tried to add AUC0\_6\_%extrap as (AUC0-6-AUClast)/(AUC0-6)\*100. But AUC0-6 was considered a variable not valid even though AUC0-6 was selected as is from the list in the Definition field. Thanks. --- ## [X-axis on Box Plots](https://forum.certara.com/t/x-axis-on-box-plots/4354)
**Author:** [@michael](https://forum.certara.com/u/michael)\ **Replies:** 0\ **Last updated:** [December 31, 2025, 7:16pm UTC](https://forum.certara.com/t/x-axis-on-box-plots/4354 "2025-12-31T19:16:39Z")
is there any talk on adding numeric as an option for the x-axis on Box Plots? I get that I can do what I want with an xy scatter and then adding means, medians, etc. --- ## [P21E v6.1.0 -\> SD1230: Value level datatype must match the datatype described in define.xml.](https://forum.certara.com/t/p21e-v6-1-0-sd1230-value-level-datatype-must-match-the-datatype-described-in-define-xml/2075)
**Author:** [@denys.hryhorenko](https://forum.certara.com/u/denys.hryhorenko)\ **Replies:** 2\ **Last updated:** [December 26, 2025, 3:13am UTC](https://forum.certara.com/t/p21e-v6-1-0-sd1230-value-level-datatype-must-match-the-datatype-described-in-define-xml/2075 "2025-12-26T03:13:15Z")
Hi Denys, This post seems to be related to a data package in P21E so I will create a ticket in ESD to investigate this and provide more information. You will receive an email notification once this has been created. Ki… --- ## [Allometric scaling animal to human](https://forum.certara.com/t/allometric-scaling-animal-to-human/3412)
**Author:** [@harishkaushik](https://forum.certara.com/u/harishkaushik)\ **Replies:** 2\ **Last updated:** [December 16, 2025, 5:56pm UTC](https://forum.certara.com/t/allometric-scaling-animal-to-human/3412 "2025-12-16T17:56:46Z")
Hello, I have preclinical PK data from 4 species (Mice,Rat,GuineaPig & Dog) i wanted to utilise the phoenix automation for predicting FIH dose and profile, I viewed the webinar by Serge it was helpful, but is there any… --- ## [Pushing dictionaries to all users](https://forum.certara.com/t/pushing-dictionaries-to-all-users/4348)
**Author:** [@Awais\_Tahir\_Contract](https://forum.certara.com/u/Awais_Tahir_Contract)\ **Replies:** 2\ **Last updated:** [November 18, 2025, 11:22pm UTC](https://forum.certara.com/t/pushing-dictionaries-to-all-users/4348 "2025-11-18T23:22:49Z")
Hi Pinnacle 21 C Team. Can you please tell me the steps how we can make sure all users within the company are using same version of dictionaries? For example MedDRA, Is there a way to centrally install or make these dic… --- ## [AD0200: ADaM/dataset variable type mismatch](https://forum.certara.com/t/ad0200-adam-dataset-variable-type-mismatch/4346)
**Author:** [@Tibi](https://forum.certara.com/u/Tibi)\ **Replies:** 3\ **Last updated:** [November 17, 2025, 4:48pm UTC](https://forum.certara.com/t/ad0200-adam-dataset-variable-type-mismatch/4346 "2025-11-17T16:48:41Z")
Hi everyone, I am getting the following error “AD0200: ADaM/dataset variable type mismatch” for all ADaM datasets when using latest P21E engine and ADaM IG 1.3. These errors were not present in earlier validations and … --- ## [Fitting Volume as a dose-dependent parameter](https://forum.certara.com/t/fitting-volume-as-a-dose-dependent-parameter/4340)
**Author:** [@chuck.locuson](https://forum.certara.com/u/chuck.locuson)\ **Replies:** 1\ **Last updated:** [November 14, 2025, 4:53pm UTC](https://forum.certara.com/t/fitting-volume-as-a-dose-dependent-parameter/4340 "2025-11-14T16:53:15Z")
My drug volume changes with dose due to TMDD (small molecule with slow off-rate) and I am looking for help how to set up the extravascular PK model that will fit a different volume for each dose level. My dose range cove… --- ## [Exclude Dose Normalised Partial Areas](https://forum.certara.com/t/exclude-dose-normalised-partial-areas/4347)
**Author:** [@njackson](https://forum.certara.com/u/njackson)\ **Replies:** 1\ **Last updated:** [November 14, 2025, 12:55pm UTC](https://forum.certara.com/t/exclude-dose-normalised-partial-areas/4347 "2025-11-14T12:55:39Z")
The dose normalised partial area parameters are autonatically generated. Is there any way to prevent this or exclude them form the results table? We export results using the CDISC export function and have to post proce… --- ## [SD2244 (Invalid TSVCDREF value for FCNTRY)について](https://forum.certara.com/t/sd2244-invalid-tsvcdref-value-for-fcntry/4344)
**Author:** [@seiko.yamazaki](https://forum.certara.com/u/seiko.yamazaki)\ **Replies:** 0\ **Last updated:** [November 5, 2025, 6:10am UTC](https://forum.certara.com/t/sd2244-invalid-tsvcdref-value-for-fcntry/4344 "2025-11-05T06:10:26Z")
SD2244に関して、PMDA 2411.0においてTSVCDREFの値を「ISO 3166」ではなく「ISO 3166-1 alpha-3」に変更しました。ただし、CDISC Conformanceルールでは、この変更はSDTM IG v3.2およびv3.3にのみ適用され、v3.4には適用されません。DICTNAMコードリストが代わりにTSVCDREFに適用されます。SDTM IG v3.4でTSVCDREF=”ISO 3166-1 … --- ## [Mixture Models with latent covariate with NLME](https://forum.certara.com/t/mixture-models-with-latent-covariate-with-nlme/4339)
**Author:** [@phychadelicpk](https://forum.certara.com/u/phychadelicpk)\ **Replies:** 1\ **Last updated:** [October 24, 2025, 6:13pm UTC](https://forum.certara.com/t/mixture-models-with-latent-covariate-with-nlme/4339 "2025-10-24T18:13:45Z")
Hi all, I am looking to reproduce a model that college developed in Monolix. They used a mixture model with a latent covariate. In my search of the manual, I see no ability to do this in NLME. I saw this confirmed by a … --- ## [Error on Phoenix](https://forum.certara.com/t/error-on-phoenix/4338)
**Author:** [@Chun\_Li](https://forum.certara.com/u/Chun_Li)\ **Replies:** 1\ **Last updated:** [October 23, 2025, 1:35pm UTC](https://forum.certara.com/t/error-on-phoenix/4338 "2025-10-23T13:35:31Z")
I have been using Phoenix for NCA and PK compartmental modeling and simulation. I have been running into the following error messages saying that “length can’t be less than zero. Parameter name: length”. This happen whe… --- ## [Multiple oral dose population PK model](https://forum.certara.com/t/multiple-oral-dose-population-pk-model/4336)
**Author:** [@sabdulm1](https://forum.certara.com/u/sabdulm1)\ **Replies:** 2\ **Last updated:** [October 21, 2025, 4:46pm UTC](https://forum.certara.com/t/multiple-oral-dose-population-pk-model/4336 "2025-10-21T16:46:37Z")
Hello, I have a PK model for a drug that is dosed once a day for three days. I have modeled the first dose well with an enterohepatic recirculation model. I want to try adding the other two doses now. I have in my origi… --- ## [Why do i have .phxlastload or .phxbackup files being created](https://forum.certara.com/t/why-do-i-have-phxlastload-or-phxbackup-files-being-created/4337)
**Author:** [@SimonDavis](https://forum.certara.com/u/SimonDavis)\ **Replies:** 0\ **Last updated:** [October 21, 2025, 9:53am UTC](https://forum.certara.com/t/why-do-i-have-phxlastload-or-phxbackup-files-being-created/4337 "2025-10-21T09:53:29Z")
i’ve had a few people ask about these and I thought it would be useful to point people to these two tip pages - essentially you can ignore them unless you need to return to previous version of a project. it’s not a repla… --- ## [Getting Error "Variable is in wrong order within domain"](https://forum.certara.com/t/getting-error-variable-is-in-wrong-order-within-domain/4332)
**Author:** [@jenny\_zhou](https://forum.certara.com/u/jenny_zhou)\ **Replies:** 3\ **Last updated:** [October 13, 2025, 2:09am UTC](https://forum.certara.com/t/getting-error-variable-is-in-wrong-order-within-domain/4332 "2025-10-13T02:09:49Z")
I am getting this error in many domain, ae cm dm etc. I have tried many sort sequence combination, but this issue still there and even in dm(which is sorted by studyid, usubjid) I am sure there is no duplicates. any i… --- ## [Enable CCLI in unix-like system](https://forum.certara.com/t/enable-ccli-in-unix-like-system/4333)
**Author:** [@flight](https://forum.certara.com/u/flight)\ **Replies:** 0\ **Last updated:** [October 11, 2025, 9:26am UTC](https://forum.certara.com/t/enable-ccli-in-unix-like-system/4333 "2025-10-11T09:26:32Z")
Hi Team, it would be very grateful if we can use CCLI in linux system in next release. Best, --- ## [How to exclude Predose from being identified as Cmax in Phoenix](https://forum.certara.com/t/how-to-exclude-predose-from-being-identified-as-cmax-in-phoenix/4325)
**Author:** [@John\_CK\_Lai](https://forum.certara.com/u/John_CK_Lai)\ **Replies:** 2\ **Last updated:** [October 9, 2025, 9:32pm UTC](https://forum.certara.com/t/how-to-exclude-predose-from-being-identified-as-cmax-in-phoenix/4325 "2025-10-09T21:32:57Z")
Hi all, I received a single dose plasma concentration-time dataset (n=50 subjects) that I will be using NCA in Phoenix to generate the standard PK parameters. The compound of interest is endogenous so there is existing… --- ## [popPK model plots dot identification and colouring](https://forum.certara.com/t/poppk-model-plots-dot-identification-and-colouring/4329)
**Author:** [@estherwinter](https://forum.certara.com/u/estherwinter)\ **Replies:** 6\ **Last updated:** [October 6, 2025, 10:19pm UTC](https://forum.certara.com/t/poppk-model-plots-dot-identification-and-colouring/4329 "2025-10-06T22:19:35Z")
Hi, In the diagnostic plot (in this case popDV vs IPRED), is it possible to identify which dot belongs to what data point? And is it also possible to give dots a colour based on e.g. gender? That would help to identify … --- ## [SD1339: Missing EPOCH value when a start or observation date is provided](https://forum.certara.com/t/sd1339-missing-epoch-value-when-a-start-or-observation-date-is-provided/4282)
**Author:** [@Pavan\_K](https://forum.certara.com/u/Pavan_K)\ **Replies:** 4\ **Last updated:** [October 6, 2025, 6:29pm UTC](https://forum.certara.com/t/sd1339-missing-epoch-value-when-a-start-or-observation-date-is-provided/4282 "2025-10-06T18:29:24Z")
We have some historical records in finding domains as they collected for historical comparison before trial start like weight of the subject. These assessments have the DTC before the informed consent date. How to popul… --- ## [Follow for Integral release updates](https://forum.certara.com/t/follow-for-integral-release-updates/4331)
**Author:** [@SimonDavis](https://forum.certara.com/u/SimonDavis)\ **Replies:** 0\ **Last updated:** [October 6, 2025, 10:00am UTC](https://forum.certara.com/t/follow-for-integral-release-updates/4331 "2025-10-06T10:00:44Z")
Most of you should have received this information by email at the beginning of September, but I reiterate it below to share information about 25.10.1, the next release of Certara Integral. Integral 25.10.1 Scope Integr… --- ## [Stratification XY spaghetti plot](https://forum.certara.com/t/stratification-xy-spaghetti-plot/4328)
**Author:** [@estherwinter](https://forum.certara.com/u/estherwinter)\ **Replies:** 2\ **Last updated:** [October 2, 2025, 8:29am UTC](https://forum.certara.com/t/stratification-xy-spaghetti-plot/4328 "2025-10-02T08:29:37Z")
Hi, I have a XY spaghetti plot, and want to stratify these by dose (part of the subjects have received a high dose and part a low dose). How do I give all the subjects with the high dose one colour and the subjects with… --- ## [PK Submit releases, new plug-in to create PK CDISC Domain](https://forum.certara.com/t/pk-submit-releases-new-plug-in-to-create-pk-cdisc-domain/3424)
**Author:** [@SimonDavis](https://forum.certara.com/u/SimonDavis)\ **Replies:** 4\ **Last updated:** [September 30, 2025, 10:28am UTC](https://forum.certara.com/t/pk-submit-releases-new-plug-in-to-create-pk-cdisc-domain/3424 "2025-09-30T10:28:33Z")
In this 30-minute webinar, you will learn about PK Submitâ„¢, a new add-on to Phoenix WinNonlin that automates the creation of PK CDISC domains during NCA analysis. It can generate both Study Data Tabulation Model (SDTM)… --- ## [Pinnacle21 check ADaM vs. SDTM](https://forum.certara.com/t/pinnacle21-check-adam-vs-sdtm/1283)
**Author:** [@Sergiy](https://forum.certara.com/u/Sergiy)\ **Replies:** 8\ **Last updated:** [September 4, 2025, 12:17am UTC](https://forum.certara.com/t/pinnacle21-check-adam-vs-sdtm/1283 "2025-09-04T00:17:25Z")
Hi Manolya, Yes, P21 validation for ADaM IG 1.1 includes traceability rules similar to ADaM IG 1.0. The execution of these rule requires adding AE, DM and EX datasets when validating ADaM data. This is very important e… --- ## [European Phoenix User Group Meetings](https://forum.certara.com/t/european-phoenix-user-group-meetings/3655)
**Author:** [@SimonDavis](https://forum.certara.com/u/SimonDavis)\ **Replies:** 3\ **Last updated:** [August 29, 2025, 11:27am UTC](https://forum.certara.com/t/european-phoenix-user-group-meetings/3655 "2025-08-29T11:27:07Z")
Please consider attending this meeting to hear about our vision for the future of the Phoenix platform and how we plan to continue to support our customers in their digital transformation Keynote speakers Dr. Cardot a… [Previous page](https://forum.certara.com/latest.md?page=1) [Next page](https://forum.certara.com/latest.md?page=3)