Anticoagulant Effect on PK

Hello Forum members/Experts

Iam trying to build PHX NLME model to analyze the impact of EDTA/HEPARIN as an anticoagulant in the Tigecycline PK data using NLME module

I have included EDTA/HEPARIN as an categorical covariate

I need your expert help in fitting the data and understanding the Anticoagulant effect

I observed that Tigecycline data follows 2 compartment post IV infusion at a dose of 5 mpk for 0.25 hrs

Iam attaching the PHX project, Paper

Regards

Harish

Tigecycline.phxproj (1.09 MB)EDTA Plasma and Tetracyclines.pdf (722 KB)