dear all whether we will get output for AUCextrapolated in winnonlin. normally we calculate AUCEXTRA=auct/auci100. but in winnonlin AUC_%Extrap _obs = aucinfobs-auct/aucinfobs100. whether we want to calculate manually for aucextrapolated.
[quote]whether we will get output for AUCextrapolated in winnonlin. normally we calculate AUCEXTRA=auct/auci100.[/quote]Slowly read your formula again. 
What you calculate here is the percentage of AUCinf which is covered by AUCt; maybe you should change the name of your variable. [quote]but in winnonlin AUC_%Extrap _obs = aucinfobs-auct/aucinfobs100.[/quote]Correct. That’s the percentage of AUCinf which is extrapolated. Therefore the name. [quote]whether we want to calculate manually for aucextrapolated.[/quote]Up to you. According to regulations extrapolated area should be ≤20% of AUCinf or AUCt should cover ≥80% of AUCinf.