Efficiently Calculating Cmax and AUC with 95% CI for 5th, 50th, and 95th Quartiles in Large Phoenix NLME Simulations

[SimonDavis]

Hi Bhim, others like Samer have more practical experience and it may be that for these larger analyses you would be better running your code via RsNLME, this is free to use for all NLME licensees as well as academia in general.
https://certara.github.io/R-RsNLME/index.html

However I think these threads about directly calculating CMax and AUC, should save you having to run secondary NCAs on these large outputs.

Simon.

PML: Calculate max value in compartment

CalcTmax can be found in the file named: Mutil.c C:\Program Files (x86)\Pharsight\Phoenix 1.4\application\lib\NLME\Executables\Mutil.c it is a function that take macro constants as input and return the time where output ( concentration) is maximum i.e Tmax. note how it uses all compartments parameters i.e alpha beta and gamma and A, B , C. The short answer is no CalcTmax only return the Tmax where the central compartment is maximum. Similar functions can be written to find the maximum for a…

Assistance calculating AUC as secondary parameter

Ian, I had meant to include this screenshot before showing how to do this, sorry for the delay; If you want AUC_t1 to t2 you can add an ODE to the model and capture the value at t2 in a table statement; e.g #deriv(AUCt1_t2 = (t>t1)*(t<t2)C) deriv(AUCt12 = (t>0)(t<12)C) deriv(AUCt12_24 = (t>12)(t<24)C) deriv(AUCt24 = (t>0)(t<24)C) deriv(AUCt999= (t>0)(t<999)*C) deriv(AUCtinf=C) Simon [AUCt_pml.jpg])*c)> [AUCt_pml.jpg]