# How to calculate pharmacokinetic parameters

**URL:** <https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661>\
**Category:** Phoenix WNL basics\
**Created:** [February 19, 2023, 12:55pm UTC](https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661 "2023-02-19T12:55:57Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![phoebe](https://avatars.discourse-cdn.com/v4/letter/p/41988e/32.png) [@phoebe](https://forum.certara.com/u/phoebe)\
**Post date:** [February 19, 2023, 12:55pm UTC](https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661/1 "2023-02-19T12:55:57Z")

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Take a 7-day dosing cycle for three times, and conduct sampling and testing in the first and third cycles. Can NCA be used for calculation?

Thank you~

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**Author:** ![SimonDavis](https://avatars.discourse-cdn.com/v4/letter/s/d9b06d/32.png) [@SimonDavis](https://forum.certara.com/u/SimonDavis)\
**Post date:** [February 19, 2023, 7:06pm UTC](https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661/2 "2023-02-19T19:06:18Z")

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Most likely yes, I would analyse first profile day as naive dose and then I assume by your third cycle you would be at SS and could then use tau in dosing panel to indicate that.

Is that the plan of your design? what is your anticipated half-life?

Simon.

(Ensure your dosing interval is consistent/always equal to use NCA SS option.)

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**Author:** ![phoebe](https://avatars.discourse-cdn.com/v4/letter/p/41988e/32.png) [@phoebe](https://forum.certara.com/u/phoebe)\
**Post date:** [February 20, 2023, 1:47am UTC](https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661/3 "2023-02-20T01:47:02Z")

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> [@sdavis](#):
>
> Most likely yes, I would analyse first profile day as naive dose and then I assume by your third cycle you would be at SS and could then use tau in dosing panel to indicate that.
> 
> Is that the plan of your design? what is your anticipated half-life?
> 
> Simon.
> 
> (Ensure your dosing interval is consistent/always equal to use NCA SS option.)

Sorry, I am a beginner, do not quite understand what you said about NCA SS.My dosing interval is consistent.

[worksheet1.xlsx](https://forum.certara.com/uploads/short-url/thm7QnxVGkPWfZPnl5rEAkDYEBf.xlsx) (15.8 KB)

Please check it for me,thank you.

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<div class="post-metadata">

**Author:** ![SimonDavis](https://avatars.discourse-cdn.com/v4/letter/s/d9b06d/32.png) [@SimonDavis](https://forum.certara.com/u/SimonDavis)\
**Post date:** [February 20, 2023, 6:58pm UTC](https://forum.certara.com/t/how-to-calculate-pharmacokinetic-parameters/3661/4 "2023-02-20T18:58:39Z")

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From you sample schedule, yes NCA looks feasible, if you get stuck later when performing your NCA, then drop us a line here - (or if confidential, please email [support@certara.com](mailto:support@certara.com))