# intrasubject CV ( replicate study)

**URL:** <https://forum.certara.com/t/intrasubject-cv-replicate-study/2457>\
**Category:** Phoenix WNL basics\
**Created:** [July 24, 2012, 11:41am UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457 "2012-07-24T11:41:34Z")\
**Posts on this page:** 6\
**Page:** 2

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**Author:** ![lhughes](https://avatars.discourse-cdn.com/v4/letter/l/ecc23a/32.png) [@lhughes](https://forum.certara.com/u/lhughes)\
**Post date:** [August 9, 2012, 4:58pm UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/21 "2012-08-09T16:58:56Z")

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I tried this in SAS (thanks to Helmet for filling in the missing lines from the Progesterone guidance), and my CV% from SAS matched Helmet’s Phoenix workflow, 33.16. However, my critbound value was different than both of the previous values given here, -0.040468, although I’ll admit I’m a poor SAS programmer and I could have errors in handling the datasets. stats06, would it be possible to get the SAS code that your company used? I attached a file with my code. Linda Hughes

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**Author:** ![Helmut\_Schuetz](https://avatars.discourse-cdn.com/v4/letter/h/eb8c5e/32.png) [@Helmut\_Schuetz](https://forum.certara.com/u/Helmut_Schuetz)\
**Post date:** [August 9, 2012, 5:20pm UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/22 "2012-08-09T17:20:30Z")

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Hi Linda! [quote]Helmet[/quote] Helmut, not Helmet. The first a name, the second not quite. 😉 [quote]CV% from SAS matched Phoenix workflow, 33.16.[/quote] Fine, but that’s not so important. [quote]However, my critbound value was different than both of the previous values given here, -0.040468[/quote] So what did you get? [quote]I attached a file with my code.[/quote] Can you please edit you post - the usual story with attached files leading to electronc nirvana (= they are not displayed as a link at all).

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**Author:** ![lhughes](https://avatars.discourse-cdn.com/v4/letter/l/ecc23a/32.png) [@lhughes](https://forum.certara.com/u/lhughes)\
**Post date:** [August 9, 2012, 5:26pm UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/23 "2012-08-09T17:26:39Z")

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Hi Helmut, Sorry about the misspelling! The critbound value I got was in my post, -0.040468. Simon is going to help me with getting the file attached. Linda

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**Author:** ![Helmut\_Schuetz](https://avatars.discourse-cdn.com/v4/letter/h/eb8c5e/32.png) [@Helmut\_Schuetz](https://forum.certara.com/u/Helmut_Schuetz)\
**Post date:** [August 9, 2012, 5:40pm UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/24 "2012-08-09T17:40:17Z")

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Hi Linda! [quote]Sorry about the misspelling![/quote] I have heard that numerous times from English speakers but never saw it written. Helmut - helmet is a running gag in Jim Jarmusch’s ‘Night On Earth’. Great movie. [quote]The critbound value I got was in my post, -0.040468.[/quote] Fits perfectly with my workflow’s -0.040467813. Good to hear. Now we have three instances where we obtained the same results as SAS. I guess stat06’s CRO screwed up. P.S.: Is the implementation of getting access to internal statistical distributions (most important Chi2, non-central t) in a custom transformation on the to-do-list?

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**Author:** ![lhughes](https://avatars.discourse-cdn.com/v4/letter/l/ecc23a/32.png) [@lhughes](https://forum.certara.com/u/lhughes)\
**Post date:** [August 9, 2012, 6:12pm UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/25 "2012-08-09T18:12:12Z")

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Hi Helmut, That’s great news! I was looking at one of the older posts that still had the typo: “critbound -0.04467813 CV(%) 33.16” So your Phoenix workflow actually yields -0.040467813, which matches my SAS. That’s excellent! About your other question, what is on the to-do list is better support for RSABE. How that will be done is still under discussion. We really appreciate your Phoenix workflows showing folks a way to do this in PHX 1.3. Linda Edit by Simon, the attached file is actually a .sas file. [file name=fastdata.txt size=2939][Certara | Drug Development Solutions](http://www.pharsight.com/extranet/media/kunena/attachments/legacy/files/fastdata.txt%5B/file%5D%5Bfastdata.txt%7Cattachment%5D(upload://7mCNtR8N3pmfQfB7Gg32jNrzq5g.txt)) (2.87 KB)

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**Author:** ![stats06](https://avatars.discourse-cdn.com/v4/letter/s/cab0a1/32.png) [@stats06](https://forum.certara.com/u/stats06)\
**Post date:** [August 10, 2012, 5:31am UTC](https://forum.certara.com/t/intrasubject-cv-replicate-study/2457/26 "2012-08-10T05:31:51Z")

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hi Linda , Thanks for confirming the answer… i am sure that the CRO did some mistake in his codes.. i have requested them to send me the same . so if they do i’ll post them here and then u can analyze them. regards, stats06

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