Least Square PK model

Phoenix Certara Forums Phoenix WNL basics
1

Hello,

In PK Model 2: IV-infusion input, 1-compartment, no lag, 1st elimination (under the Least-squares regression models), V (volume) is one of the estimated parameters whereas Vss is a clearance secondary parameters. What is the V here? the Vz, Vc or ? How is Vss calculated in this case?

Thank you very much for your help.

SJ

2

Hi,

there is detailed information in our online help:

https://onlinehelp.certara.com/phoenix/8.3/index.html#t=topics%2Fpkmodelcalc.htm%23TOC_Model_2bc-2&rhtocid=_33_3_4_1

You can find information about the formula for secondary parameters by:

  1. insert a Phoenix Model object into your workflow

  2. Setting a WNL model:

wnl.png
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  1. pick Model 2 and click Apply

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  1. look at Parameters>>Secondary Tab in the bottom panel:

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Let me know if this does not help.

Bernd