# May 16 webinar by Wojciech Krzyzanski **URL:** \ **Category:** Modelling and Simulation\ **Created:** [March 31, 2017, 5:51pm UTC](https://forum.certara.com/t/may-16-webinar-by-wojciech-krzyzanski/3154 "2017-03-31T17:51:18Z")\ **Posts on this page:** 4\ **Page:** 1
**Author:** ![cmatsumura](https://avatars.discourse-cdn.com/v4/letter/c/9fc348/32.png) [@cmatsumura](https://forum.certara.com/u/cmatsumura)\ **Post date:** [March 31, 2017, 5:51pm UTC](https://forum.certara.com/t/may-16-webinar-by-wojciech-krzyzanski/3154/1 "2017-03-31T17:51:18Z")
Modeling PK/PD Systems with Distributed Delays **Speaker(s):** Wojciech Krzyzanski **Date:** May 16, 2017 **Time:** 11 am EST Systems with distributed delays are extensions of systems with discrete delays where a single lag time is represented by a distribution of lag times. Distributed absorption times for orally administered drugs serve as an example of a pharmacokinetic (PK) system with distributed delays. Another example is a hematopoietic cell population with distributed lifespans. The topic of this webinar is to introduce mathematical tools to model pharmacokinetic/pharmacodynamic (PK/PD) systems with distributed delays. These models will be implemented in Phoenix NLME by means of the delay() operator. A distributed delay version of the transit compartment model for oral drug absorption will be provided. A distributed lifespan PD model of RBC production will be also discussed. **About Our Speaker** Dr. Wojciech Krzyzanski is an Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB). Dr. Krzyzanski holds a PhD in applied mathematics and a MA in pharmacology. His PK/PD modeling interests and capabilities include the modeling of pharmacokinetics and pharmacodynamics of hematopoietic growth factors, the model-based development of optimal dosing regimens for chemotherapy induced cytotoxicities, particularly myelosuppression, the pharmacometric analysis of properties of various types of indirect response models, and the evolution of target-mediated PK/PD models. Register for the [webinar](https://www.certara.com/webinars/modeling-pkpd-systems-with-distributed-delays/) ---
**Author:** ![krinaj](https://avatars.discourse-cdn.com/v4/letter/k/d2c977/32.png) [@krinaj](https://forum.certara.com/u/krinaj)\ **Post date:** [June 30, 2017, 11:12pm UTC](https://forum.certara.com/t/may-16-webinar-by-wojciech-krzyzanski/3154/2 "2017-06-30T23:12:47Z")
> [@cmatsumura](#): > > Modeling PK/PD Systems with Distributed Delays > > **Speaker(s):** Wojciech Krzyzanski > **Date:** May 16, 2017 > **Time:** 11 am EST > > Systems with distributed delays are extensions of systems with discrete delays where a single lag time is represented by a distribution of lag times. Distributed absorption times for orally administered drugs serve as an example of a pharmacokinetic (PK) system with distributed delays. Another example is a hematopoietic cell population with distributed lifespans. > > The topic of this webinar is to introduce mathematical tools to model pharmacokinetic/pharmacodynamic (PK/PD) systems with distributed delays. These models will be implemented in Phoenix NLME by means of the delay() operator. A distributed delay version of the transit compartment model for oral drug absorption will be provided. A distributed lifespan PD model of RBC production will be also discussed. > > **About Our Speaker** > > Dr. Wojciech Krzyzanski is an Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB). Dr. Krzyzanski holds a PhD in applied mathematics and a MA in pharmacology. His PK/PD modeling interests and capabilities include the modeling of pharmacokinetics and pharmacodynamics of hematopoietic growth factors, the model-based development of optimal dosing regimens for chemotherapy induced cytotoxicities, particularly myelosuppression, the pharmacometric analysis of properties of various types of indirect response models, and the evolution of target-mediated PK/PD models. > > Register for the [webinar](https://www.certara.com/webinars/modeling-pkpd-systems-with-distributed-delays/) I found recording of this webinar on youtube, and found it very useful. Do you by chance have pdf of slides to share? thanks, Krina ---
**Author:** ![Samer\_Mouksassi](https://avatars.discourse-cdn.com/v4/letter/s/ce7236/32.png) [@Samer\_Mouksassi](https://forum.certara.com/u/Samer_Mouksassi)\ **Post date:** [July 6, 2017, 2:26pm UTC](https://forum.certara.com/t/may-16-webinar-by-wojciech-krzyzanski/3154/3 "2017-07-06T14:26:08Z")
Ideally, to make these webinars even more useful we should upload and link the Phoenix projects that were shown. Can we reach out to Professor Krzyzanski to get them? Bests, Samer ---
**Author:** ![cmatsumura](https://avatars.discourse-cdn.com/v4/letter/c/9fc348/32.png) [@cmatsumura](https://forum.certara.com/u/cmatsumura)\ **Post date:** [July 10, 2017, 4:31pm UTC](https://forum.certara.com/t/may-16-webinar-by-wojciech-krzyzanski/3154/4 "2017-07-10T16:31:48Z")
> [@krinaj](#): > > I found recording of this webinar on youtube, and found it very useful. Do you by chance have pdf of slides to share? > > thanks, > Krina Hi Krina, [DistributedDelays\_webinar.pdf](https://forum.certara.com/uploads/short-url/b6DksOpIcnt1shy2YU4wsjq1Oo2.pdf) (1.16 MB)