# Obtaining PK parameters with Phoenix Winnolin

**URL:** <https://forum.certara.com/t/obtaining-pk-parameters-with-phoenix-winnolin/2622>\
**Category:** Integral and other enterprise features\
**Created:** [September 8, 2013, 4:25pm UTC](https://forum.certara.com/t/obtaining-pk-parameters-with-phoenix-winnolin/2622 "2013-09-08T16:25:41Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![olumuyiwa](https://avatars.discourse-cdn.com/v4/letter/o/8baadc/32.png) [@olumuyiwa](https://forum.certara.com/u/olumuyiwa)\
**Post date:** [September 8, 2013, 4:25pm UTC](https://forum.certara.com/t/obtaining-pk-parameters-with-phoenix-winnolin/2622/1 "2013-09-08T16:25:41Z")

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I gave 600mg of a drug at 0, 24 and 48 h and obtain plasma concentration of the drug from the volunteers at time 0, 0.5, 1, 2, 4, 6, 12, 24, 48, 72, 168, 336 and 506 h. How do I proceed to obtain PK parameters using NCA of Phoenix Winnolin 6.3 giving these multiple doses?

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**Author:** ![SimonDavis](https://avatars.discourse-cdn.com/v4/letter/s/d9b06d/32.png) [@SimonDavis](https://forum.certara.com/u/SimonDavis)\
**Post date:** [September 10, 2013, 7:58pm UTC](https://forum.certara.com/t/obtaining-pk-parameters-with-phoenix-winnolin/2622/2 "2013-09-10T19:58:10Z")

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Dear Muyiwa, Have you tried following Chapter 1 in the Phoenix WinNonlin 6.3 Examples Guide.pdf, this can be easily opened using Help Menu and looking under Documents? What information are you hoping to gather/assess/report? (NCA is typically performed after a single dose event, or at steady-state) You describe that the subjects were dosed 3 times, if you want to assess each dose individually then you will need to find a way to separate each dose profile, perhaps by using filter on nominal time. If you can perhaps load up a project containing your data and what you’ve tried so far then we can advise you further. Simon.