# PK 3 Compartment IV Bolus QRPEM/IMP

**URL:** <https://forum.certara.com/t/pk-3-compartment-iv-bolus-qrpem-imp/3190>\
**Category:** NLME-NONMEM model comparisons\
**Created:** [June 27, 2017, 5:31pm UTC](https://forum.certara.com/t/pk-3-compartment-iv-bolus-qrpem-imp/3190 "2017-06-27T17:31:31Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![chrism](https://avatars.discourse-cdn.com/v4/letter/c/47e85d/32.png) [@chrism](https://forum.certara.com/u/chrism)\
**Post date:** [June 27, 2017, 5:31pm UTC](https://forum.certara.com/t/pk-3-compartment-iv-bolus-qrpem-imp/3190/1 "2017-06-27T17:31:31Z")

</div>

This is a PK 3 compartment model with IV bolus administration and clearance parameterization.

In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help \> Contents \> Phoenix Model \> Phoenix Model Run Modes, Engines, and Output \> Phoenix Model Engines \> QRPEM.

In NONMEM, the model engine is Importance Sampling (IMP) EM.

For model translation information, refer to the attached slide deck.

[attachment=3096:NONMEM to NLME Translation PK 3comp IV Clearance QRPEM IMP.pdf]

The model is run in both NLME and NONMEM in the attached Phoenix project file.

[attachment=3097:3Comp\_IV\_bolus\_clearance\_QRPEM\_IMP.phxproj]  
[NONMEM to NLME Translation PK 3comp IV Clearance QRPEM IMP.pdf](https://forum.certara.com/uploads/short-url/v8IYgR9MSgM9YEAchG7ADLwbzfa.pdf) (1.31 MB)[3Comp\_IV\_bolus\_clearance\_QRPEM\_IMP.phxproj](https://forum.certara.com/uploads/short-url/cKbPzi3y03x70yKrnPpNIkHZM9e.phxproj) (2.68 MB)