# PK Inhibitory Emax 1 compartment Oral dosing QRPEM/IMP

**URL:** <https://forum.certara.com/t/pk-inhibitory-emax-1-compartment-oral-dosing-qrpem-imp/3203>\
**Category:** NLME-NONMEM model comparisons\
**Created:** [July 19, 2017, 8:25pm UTC](https://forum.certara.com/t/pk-inhibitory-emax-1-compartment-oral-dosing-qrpem-imp/3203 "2017-07-19T20:25:35Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![chrism](https://avatars.discourse-cdn.com/v4/letter/c/47e85d/32.png) [@chrism](https://forum.certara.com/u/chrism)\
**Post date:** [July 19, 2017, 8:25pm UTC](https://forum.certara.com/t/pk-inhibitory-emax-1-compartment-oral-dosing-qrpem-imp/3203/1 "2017-07-19T20:25:35Z")

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This is a 1 compartment PK/Emax model with a single Oral dose and **inhibitory** PD.

In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help \> Contents \> Phoenix Model \> Phoenix Model Run Modes, Engines, and Output \> Phoenix Model Engines \> QRPEM.

In NONMEM, the model engine is Importance Sampling (IMP) EM.

For model translation information, refer to the attached slide deck.

[NONMEM\_NLME\_TRANSLATION\_1Comp\_Oral\_PK\_Emax\_Inhibitory\_QRPEM\_IMP.pdf](https://forum.certara.com/uploads/short-url/aq0xY9ie3pqjMcnRQAalxVX9unv.pdf) (741 KB)

The model is run in both NLME and NONMEM in the attached Phoenix project file.

[1Comp\_Oral\_PK\_Imax\_QRPEM\_IMP.phxproj](https://forum.certara.com/uploads/short-url/u06WAwfM3hHBdMGCu7TYKCsxMA0.phxproj) (2.24 MB)