Hi, I want to simulate the model of ST-246, published in 2013 in AAC (PMID:23254433), for which Pharsight consulted. I have two questions. 1) the paper does not give enough information to code additive + proportional error. I know Eps = 10.92 ug/L, but stdev(Eps) is not reported, and I would need this to calculate the cmixratio, correct? 2) the paper does not say if a blocked omega matrix is used or not. if it was, can you provide the diagonal parameter values?
Hi, In order to send information that was not in the paper we will need to ask first the corresponding author in the paper. Although Pharsight did the consulting this is proprietary information owned by Siga. Please email me at smouksassi@pharsight.com and we will take it from there. Samer