# Simulating multiple dose using Phoenix Model

**URL:** <https://forum.certara.com/t/simulating-multiple-dose-using-phoenix-model/2263>\
**Category:** Phoenix WNL basics\
**Created:** [February 23, 2011, 1:13am UTC](https://forum.certara.com/t/simulating-multiple-dose-using-phoenix-model/2263 "2011-02-23T01:13:09Z")\
**Posts on this page:** 3\
**Page:** 1

<div class="post-metadata">

**Author:** ![rluo](https://avatars.discourse-cdn.com/v4/letter/r/a698b9/32.png) [@rluo](https://forum.certara.com/u/rluo)\
**Post date:** [February 23, 2011, 1:13am UTC](https://forum.certara.com/t/simulating-multiple-dose-using-phoenix-model/2263/1 "2011-02-23T01:13:09Z")

</div>

Hello, I have fitted Day-1 human PK data using Phoenix model, and I would like to use this model simulation multiple dose exposure to guide the study design. The only way I could find using a PK model (rather than nonparametric superposition) for simulation is under WNL5 classic models, which doesn’t fit the data very well at all. Is there any way to do the simulation under Pheonix model? Thanks! Best, Rosa

---

<div class="post-metadata">

**Author:** ![bwendt](https://avatars.discourse-cdn.com/v4/letter/b/f4b2a3/32.png) [@bwendt](https://forum.certara.com/u/bwendt)\
**Post date:** [February 24, 2011, 9:14am UTC](https://forum.certara.com/t/simulating-multiple-dose-using-phoenix-model/2263/2 "2011-02-24T09:14:02Z")

</div>

Dear Rosa, please have a look at the Run Options tab of the Phoenix Model object where you have given the choices for the different Run Modes, Simulation is one option. Best, Bernd

---

<div class="post-metadata">

**Author:** ![rluo](https://avatars.discourse-cdn.com/v4/letter/r/a698b9/32.png) [@rluo](https://forum.certara.com/u/rluo)\
**Post date:** [March 2, 2011, 10:21pm UTC](https://forum.certara.com/t/simulating-multiple-dose-using-phoenix-model/2263/3 "2011-03-02T22:21:24Z")

</div>

Hi Bernd, Thanks! I figured it out finally 🙂 I need to “un-map” the concentration from CObs. Best, Rosa