# Target-mediated Drug Disposition (TMDD) Modeling Using the Quasi-equilibrium Assumption

**URL:** <https://forum.certara.com/t/target-mediated-drug-disposition-tmdd-modeling-using-the-quasi-equilibrium-assumption/3239>\
**Category:** PML School\
**Created:** [November 30, 2017, 8:06pm UTC](https://forum.certara.com/t/target-mediated-drug-disposition-tmdd-modeling-using-the-quasi-equilibrium-assumption/3239 "2017-11-30T20:06:39Z")\
**Posts on this page:** 2\
**Page:** 1

<div class="post-metadata">

**Author:** ![bwendt](https://avatars.discourse-cdn.com/v4/letter/b/f4b2a3/32.png) [@bwendt](https://forum.certara.com/u/bwendt)\
**Post date:** [November 30, 2017, 8:06pm UTC](https://forum.certara.com/t/target-mediated-drug-disposition-tmdd-modeling-using-the-quasi-equilibrium-assumption/3239/1 "2017-11-30T20:06:39Z")

</div>

Here are the materials of our session about TMDD QE approximation Model:

**Phoenix project file with model:**

[attachment=3179:PML school TMDD QE approximation.phxproj]

**Slide deck** :

[attachment=3180:TMDD QE approximation.pdf]

**Link to the recorded session:**

[https://certara.webex.com/certara/lsr.php?RCID=6bfa47f8649bf5800ad8184dede01ab3](https://certara.webex.com/certara/lsr.php?RCID=6bfa47f8649bf5800ad8184dede01ab3)

[PML school TMDD QE approximation.phxproj](https://forum.certara.com/uploads/short-url/jIfvT7S6gIzpdfDfI0MFN6BYUiQ.phxproj) (1.79 MB)[TMDD QE approximation.pdf](https://forum.certara.com/uploads/short-url/bMiEmEZ8SVecR1cVDUbjqxf91Qz.pdf) (751 KB)

---

<div class="post-metadata">

**Author:** ![bwendt](https://avatars.discourse-cdn.com/v4/letter/b/f4b2a3/32.png) [@bwendt](https://forum.certara.com/u/bwendt)\
**Post date:** [December 1, 2017, 11:02am UTC](https://forum.certara.com/t/target-mediated-drug-disposition-tmdd-modeling-using-the-quasi-equilibrium-assumption/3239/2 "2017-12-01T11:02:20Z")

</div>

Here is also the link to the recorded session on Youtube:

[http://bit.ly/2j6PcjV](http://bit.ly/2j6PcjV)

And per popular request the Phoenix project file with the model and simulation objects for Phoenix 1.4 (WinNonlin 6.4):

[PML School TMDD QE Approximation\_64.phxproj](https://forum.certara.com/uploads/short-url/pKZS2q5K2ocJ5Sb17RjrdA1oLT9.phxproj) (1.42 MB)