Allomertic scaling of unbound clearance and volume of distribution

Dear All,

Please guide me below mentioned question:

We have mice, rat and dog pharmacokinetic data of molecule X

All species have significant protein binding difference.

During allometry we used CL/fraction unbound(with rule of exponent) and V/fraction unbound for allometric scaling.

Q. Clearance and volume of distribution obtained by allometric scaling (considering CL/fraction unbound(with rule of exponent) and V/fraction unbound) are total clearance and volume of distribution of human (not unbound)??

Q. let me know any thing i missed during scaling of molecule X having protein binding difference between species.

Best Regards,

Vallabh mahjan