Dear All,
Please guide me below mentioned question:
We have mice, rat and dog pharmacokinetic data of molecule X
All species have significant protein binding difference.
During allometry we used CL/fraction unbound(with rule of exponent) and V/fraction unbound for allometric scaling.
Q. Clearance and volume of distribution obtained by allometric scaling (considering CL/fraction unbound(with rule of exponent) and V/fraction unbound) are total clearance and volume of distribution of human (not unbound)??
Q. let me know any thing i missed during scaling of molecule X having protein binding difference between species.
Best Regards,
Vallabh mahjan