Allometric scaling animal to human

Phoenix Certara Forums Modelling and Simulation
1

Hello,

I have preclinical PK data from 4 species (Mice,Rat,GuineaPig & Dog)

i wanted to utilise the phoenix automation for predicting FIH dose and profile, I viewed the webinar by Serge it was helpful, but is there any way that i can use that code/ phoenix automation for my purpose

Regards

Harish

2

Hi Harish, Serge’s video was a proof of concept template he made, let me look around and see what I can find to help you; in the mean time these links maybe useful. This recorded lesson shows an example of implementing allometric scaling in Phoenix, and also has a text model example file:

https://support.certara.com/forums/topic/1013-lesson-9-allometric-scaling/

you could try modifying the text model file provided there, use it with your own data, and post any questions or issues with that model to this thread. Don’t forget to read the Q and A too.

https://support.certara.com/forums/topic/1016-qa-from-lesson-9-allometric-scaling/

Simon.