ASOP Workshop on PHX NLME The location will be: Marriott, San Diego Hotel & Marina, 333 West Harbor Drive, San Diego, Ca 92101 The official Dates are: 9/20 & 9/21. Phoenix Non Linear Mixed Effect Modeling Workshop: An integrated tool for Population PK/PD Modeling and Simulation (2 Days hands on Workshop) Outline Phoenix NLME is a user-friendly software that provides sophisticated algorithms and powerful and flexible data processing and modeling tools for population PK/PD analyses. It shares the same easy to use graphical interface as Phoenix WinNonlin and it is fully integrated with other Phoenix products. The most widely used approximate likelihood methods such as FO, FOCE (both Lindstrom-Bates and Extended Least Squares variants) and LAPLACE are supported. In addition, more accurate likelihood methods such as parametric Adaptive Gaussian Quadrature and a state-of-the-art nonparametric algorithm are available, as is a naive pooled algorithm. Recently a third accurate likelihood NLME method called QRPEM has been added. It can be compared to NONMEM IMP and IMPMAP that were recently implemented in NONMEM7. The workshop will concentrate on the different functionalities Phoenix NLME provides from how to define models using built-in PK/PD libraries available, to a graphical model builder (“edit graphical) or writing code (“edit textual”). The “edit graphical” feature allows the user to describe all the dynamic processes that characterize the system they want to model. If the “edit graphical” is not sufficient to describe the entire system, then the user can shift to the “edit as textual” mode. Library models or models defined graphically are automatically translated into a Phoenix Modeling language (PML) that can then be edited. This workshop is designed to provide hands-on experience with the software to practice the topics discussed. Each participant should bring a computer to the workshop. Educational objectives Population PK/PD is not an easy task and requires sophisticate skills to enable optimal analysis. The participants will learn how to approach any population PK/PD problem using a series of well-defined steps, each supported fully within the Phoenix environment and bringing to the solution of simple to most complex PK/PD problems. These include the use of outstanding graphical tools (front and back end), fully developed database management tools, Non Compartmental Analysis, individual Compartmental Analysis and run time interactive simulations to facilitate initial estimates for the model parameters. Finally, a new Population algorithm called QRPEM has been implemented. The methodology is similar to the MCPEM algorithm but with a more efficient sampling algorithm that improves the overall run time significantly. Purpose and final results for the participants. The purpose of this workshop is to expose the students to a new integrated approach to Population PK/PD analysis. Minimum of effort with maximum efficiency is the result of this new platform. The idea of the Phoenix environment is also to enable scientists from multiple disciplines to solve PK/PD problems at different levels and target not only the expert modelers but scientists from other disciplines like Clinical Pharmacology, engineering and Medicine.
Official Announcement and now to register PharmPK ISoP Workshop: September 20-21, 2012 in San Diego, CA Dear colleague, It is our pleasure to announce a 2-day hands-on ISoP workshop: Non Linear Mixed Effect Modeling with Phoenix. The instructor for this workshop is Serge Guzy. To register, visit http://www.go-isop.org/attend Date: September 20-21, 2012 Workshop fee (includes coffee and lunch on both days): $875.00 for ISoP members $675.00 for ISoP members (trainees) $1,175.00 for non-ISoP members $975.00 for ASCPT members $975.00 for ACCP members San Diego Marriott Marquis & Marina 333 West Harbor Drive San Diego, Ca 92101 Phone 1-619-234-1500 http://www.marriott.com/hotels/travel/sandt-san-diego-marriott-marquis-and- marina/ Educational Objectives The participants will learn how to approach pharmacometric problems using a series of well-defined steps, each supported fully within the Phoenix environment, to solve simple to most complex pharmacometric problems. These include the use of outstanding graphical tools (front and back end), fully developed database management tools, Non Compartmental Analysis, individual Compartmental Analysis, Population PK/PD analyses and run time interactive simulations to facilitate initial estimates for the model parameters. Purpose and Final Results for the Participants The purpose of this workshop is to expose the students to a new integrated approach to Population PK/PD analyses. Minimum of effort with maximum efficiency is the result of this new platform. The idea of the Phoenix environment is also to enable scientists from multiple disciplines to solve pharmacometric problems at different levels and target not only the expert modelers but scientists from other disciplines like Clinical Pharmacology, Discovery/Pre-clinical, Engineering and Medicine. Instructor Serge Guzy is president of POP-PHARM and a noted consultant with more than 20 years of experience in PK/PD population modeling and algorithm and software development. He co-developed (with Bob Bauer) the MCPEM algorithm implementation within a Population PK/PD framework. This algorithm now appears in S-ADAPT and forms the basis for the IMPEM algorithm in NONMEM 7. Registration is limited to 50 participants so early registration is suggested. To register, visit http://www.go-isop.org/attend We look forward to your attendance and participation! Suggestions and/or questions? Please contact Enrico Smith at connect@go-isop.org.