Dear All,
is there a method to perform a bayesian posthoc estimation of individual pharmacokinetic parameters in Phoenix/NLME that would be comparable to what is achieved in NONMEM using the
$est maxeval=0 posthoc
command?
I recently saw that approached being used to evaluate if experimental PK observations could
be described by e.g. a literature derived model.
Many Thanks,
Roland
Dear Roland,
From Phoenix version 7.0 onwards, the posthoc estimates (EBEs) are in a worksheet in the output by default (see image posthoc.gif). In previous versions, you can request posthoc estimates using a table statement in the run options (see dataposthoc.gif). The output will be labeled Table01.
Hope this helps,
Ana
Dear All,
is there a method to perform a bayesian posthoc estimation of individual pharmacokinetic parameters in Phoenix/NLME that would be comparable to what is achieved in NONMEM using the
$est maxeval=0 posthoc
command?
I recently saw that approached being used to evaluate if experimental PK observations could
be described by e.g. a literature derived model.
Many Thanks,
Roland
assuming you accepted all final estimates as initial you can only do the post hoc part by having N iter: 0
note that depending of methods used e.g. FOCE-ELS the individual posthoc are part of the algorithm versus the FO algorithm where we had to really do a post hoc step at the end.
There is no equivalent to NOPOSTHOC option so you always get the posthoc steps and parameters in phoenix nlme.
Many thanks for your answers, much clearer now.
Best Regards
Roland
