Calculating AUC for when dosing morning and afternoon

Hello All

I am trying to calculate AUC 0-12 hours using actual time points.
The study that I am working on is dosing twice a day oral every 12 hours.
The actual times I have are for example, 0, 2, 6, 11.9, 13, 14, 18, 23.9 hours.

What is the best approach to accurately calculate AUC 0-12 for first morning dose and then afternoon dose? Should I split the data into AM and PM, then use AUClast (which will calculate up to 11.9 hours) or tau (up to 12 hours)?

For PM, I have tried inputting all time points (0-23.9 hours) into NCA object and taking partial area using time point 12-24. Since I do not have an actual 12 hour time point, how do I calculate AUC 0-12hours for the afternoon dose?

I would suggest to post your project since there may be some data dependencies and it is clearer to illustrate with a real example.

Yes for NCA you need to treat each dose event as it’s own profile, so you need to split/sort by the dose time.

My recommendation would be to request a partial area of 0_12, but if no Lz is automatically calculated it can’t extrapolate the last 0.1 h, but maybe you can request a Lz just to make that extapolation e..g just the last 2 points.

Simon.