CVs in BE studies

Hi! I had some discussions last May with the developers about CVs. Regrettably it didn’t ‘make’ it into v6.2… Intrasubject CV for a standard 2×2 XOver is included, but intersubject CV is still wrong. See: Midha KK, Ormsby ED, Hubbard JW, McKay G, Hawes EM, Gavalas L and IJ McGilveray Logarithmic Transformation in Bioequivalence: Application with Two Formulations of Perphenazine J Pharm Sci 82/2, 138-144 (1993) Hauschke D, Steinijans VW and E Diletti Presentation of the intrasubject coefficient of variation for sample size planning in bioequivalence studies Int J Clin Pharmacol Ther 32/7, 376-378 (1994) CVw = sqrt(exp(MSEw)-1) intra (within) subject CV CVb = sqrt(exp(MSEb-MSEw)/2)-1) inter (between) subject CV CVt = sqrt(exp(MSEb+MSEw)/2)-1) total CV PHX calculates CVb as sqrt(exp(MSEb)-1) No CVs are calculated for higher-order XOvers (latin squares with more than 2 treatments, Williams’ designs).