Hello,
I performed a deconvolution to obtain the release rate of a long-acting implant by inputting the unit impulse response of the IV formulation of the drug alongside mapping the subcutaneous conc v time profiles. I’ve successfully achieved release rates and have good overlap in the pred v dv plots in the deconvolution results tab.
However, the subcutaneous formulation for which I performed this deconvolution has a bioavailability of ~40%. Given this, I interpreted the deconvolution results to be an underestimation of the release rate of the implant (since absorption function = sq disposition function / iv disposition function).
Is this a correct way of thinking about the results? Also, is there a way I could incorporate the bioavailability into the deconvolution process to obtain a more accurate release rate (I considered multiplying the sq observed concentrations by 2.4 to “convert” concentrations as if F = 1). Some individuals have recommended me use IVIC but I don’t know much about it - so any pointers help!
Daniel (PK fellow)
