Dose normalization PK

Phoenix Certara Forums Phoenix WNL basics
1

Dear Sirs,

During NCA analysis, Phoenix WinNonlin can generate the dose normalized Cmax_D (Cmax divided by dose) parameter if different dose levels between the Test and Reference product are administered.

However, if dose normalization is required the NCA results (Final parameters pivotal) include the AUClast but not the dose normalized parameter AUClast_D (AUClast divided by dose).

In other words, how can we generate AUClast_D in the NCA results?

Thank you.

Martha

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AUCtz_DN.jpg
AUCtz_DN.jpg906×579 93.2 KB

I hope the attached example project demonstrates this.

Simon

AUCtz_DN.phxproj (342 KB)