Hello Pharsight, I wanted to ask whether the NCA object is capable of assessing the time and/or area above a threshold for the Drug Effect setting over a multiple-dose regimen. it seems despite inserting a repeat dose regimen the applicaiton only assess the final dose. I wanted to calculate the time the drug concentration is above a threshold for a drug given on monday, wednesday and friday with a 2-day rest before we administer the next dose. Seems we can only evaluate this for only a single-dose or the last dose in regimen. Please confirm if there is a setting I’m missing or this is simply the limitation of the NCA object. I don’t have the option of modeling the data at the moment. thanks Elliot
Elliot, it’s a limitation of NCA theory; but I think I have a simple enough workaround, simply create a column that is time from first dose and then you can assess all the data as a single profile, if that is indeed what you want to achieve. E.g total auc over these consecutive doses. Simon
Elliot, it’s a limitation of NCA theory; but I think I have a simple enough workaround, simply create a column that is time from first dose and then you can assess all the data as a single profile, if that is indeed what you want to achieve. E.g total auc over these consecutive doses. Simon
Thanks Simon, logically it makes sense. From eyeballing it seems to give the correct answer. so I’ll use it for rough estimation. thanks for the idea! Elliot