Hi everyone, I would like to calculate the EC80 using Phoenix modeling, since the original setting only calculates EC50, Emax and gamma. I’m using a sigmoid Emax model, uniform weighting, and Emax fixed at 100. What should I do to output EC80 and its stderr as well? Thanks! Alex
Alex, With EC50, you can calculate EC whatever, by definition, EC80 is the drug concentration that gives 80% of Emax. In the sigmoid equation, replace E with 0.8*Emax and solve for C, then you will have EC80=(0.8/(1-0.8))**(1/GAMMA)*EC50 I am still on WNL 5.2. I believe in Phoenix, there should be a similar block that let you define secondary parameters Hope this helps. Jun Shen Seventh Wave Labs
Hi Jun, Thank you so much! It did work!! Thank you for the equation! I really appreciate! Alex