I’m fairly new to WNL and have been using Phoenix 8.1 just recently. I’ve mostly worked with single-dosing using NCA.
I have tried to combine single-dosing (0-24hours) and repeated dosing data (steady-state timepoints) in one full analysis but I keep encountering this error msg “ERROR: 14061: No data in steady state dosing interval; program terminating.” Although I am able to execute, I am prompted to see text output for details as final parameters could not be generated.
I have indicated tau to be 24 hours, since drug was administered once per day; continuously for 14 days.
Time points for first 24 hours are 0, 15min, 30min, 1h, 2h, 4h, 6h, 8h, 8h, 24h. Steady-state is expected after day 5. Subsequent sampling were taken at day 6, day 13 and day 20.
THX! I see that you mastered one of the secrets: Always give the dose in the same mass-unit as the concentration.
You sorted both for SN and Subject_ID. That’s not necessary because they are unique. Any one of them is enough.
Now for the problem – which is impossible to solve with NCA and your data. In the last interval you have just one concentration >LOQ. Hence, the Error message is correct.
You could only try modeling. BTW, the concentrations of the first subject decreased. Maybe you have to deal with saturation.
For the future: If possible, sample the entire steady state profile. Try to get at least the last three pre-dose samples (in your example days 18, 19, 20).
Thanks so much for your input. We have chosen the following time points on the basis that steady-state will be reached by Day 5. (ie. Day6, Day 13, Day 20).
Could you advise how I could do modeling to make use of the data after 24hours? I’ve only done NCA and have not wandered into the realm of modeling yet.
