Dear All, I am facing difficulty in fitting Insulin PK data in healthy human after iv injection data is having baseline numbers and after IV doseing. Profile looks like PO/Sc profile Can i write sleep seqence statement in phoenix or Step statement in berlkely madonna. Profile is given below Time (min) conc pM 0 14 2 763 3 973 4 763 6 493 8 210 10 70 15 17 20 10 30 23 45 13 Could you pls guide me regarding fitting Thanks Raj
Raj, Have you looked at the modelling Language reference guide in the folder; C:\Program Files (x86)\Pharsight\Phoenix\docs which contains some details and also an example “One-compartment model with sleep statement”. there is a SEQUENCE example too. If you can’t get your code to work after reviewing those then please attach your project here and hopefully we can help you further. Simon.
Thanks Simon for you quick response. Problem with this data is after IV inj max conc is coming at end time point. So its not looking like IV profile…I facing in fitting this profile Attached pls find the file of raw data and profile. [file name=GLP_1_PK_data.xlsx size=14798]Certara | Drug Development Solutions (14.5 KB)