Does anyone have any context as to why the below listed matrix is listed as not positive-definite
ranef(block(nV, nCl0, nClss) = c(0.663, 0.6934, 0.746, 0.764, 0.388, 0.634), diag (nTlag, nKa, Kind )= c(0.304, 0.965, 1.25))
Hi Lance,
was this omega estimated by nlme or nonmem ?
may times because of precision issue ( not enough significant digits output an Omega matrix can be flagged as not positive definite. Make sure that you use all the digits from the full omega outputs.
Bests,
Samer