Metabolite gut formation

Phoenix Certara Forums Modelling and Simulation
1

Hi, I am trying to fit a parent drug dosed orally with an active metabolite. I need to estimate the amount of the drug converted to the metabolite in the gut in addition to the amount formed by metabolite formation in plasma. I searched forums and I found a similar question from one member, but the question has not been answered.

https://support.certara.com/forums/topic/928-lesson-2-parent-and-metabolite-kinetics/?p=4236

​Can I get help especially with the first question.

2

Hi David,

The attaced link will give you the information on how you could build a modle (graphical and then into PML).

https://support.certara.com/forums/topic/928-lesson-2-parent-and-metabolite-kinetics/

https://www.youtube.com/watch?v=kKS4uWLrS-4

Please let me know if this is what you are looking for.

Kind regards

Mouli