I am simulating multiple dose 2 Comp PK Profile for short IV infusions using WinNonlin 7. I noticed that PK Profile changes based on # Points used in simulation. For 1-2000 hr (X axis) comparing 100 vs 2000 # point (6 doses), # 100 showed variable Cmax values between different cycles where as # 2000 appeared to be consistent. I guess this can happen because of large DT. So is there a way to decide appropriate # points based on time scale or dosing regimen?
Dear abpkpd!
If you are talking about infusion, the closer is sampling time to the end of infusion, closer the Cmax value to the exact one
Hope it helps,
Mittyright
Also if you build your model in Phoenix engine instead then you can request a table (under Run options) where you ask the specific times or sequences of times that you would like to have predicted concentrations.
Simon.