Hello,
I created a model to simultaneously predict the concentration time profile for a parent compound and metabolite for three different routes of administration (IV, PO, inhalation) using the NLME Pop PK in Phoenix.
The model with IV and Inhalation is working as intended which is labeled as “IV and Inh THC 11OHTHC FO” in the attached file.
When I add the oral route of administration “PO, IV and Inh THC 11OHTHC FO”, there is no simulated profile for the parent or metabolite via the oral route.
Does anyone have any ideas why this is happening?
Thank you,
Adi
Issue was solved by changing the absorption equations.