This is a 1 compartment PK Emax model with IV Bolus dosing, fit using First Order Conditional Estimation (FOCE). For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.
[attachment=3112:NONMEM_NLME_TRANSLATION_1Comp_PK_Emax_FOCE.pdf]
[attachment=3113:1Comp_IV_Bolus_PK_EMAX.phxproj]NONMEM_NLME_TRANSLATION_1Comp_PK_Emax_FOCE.pdf (1.88 MB)1Comp_IV_Bolus_PK_EMAX.phxproj (1.99 MB)