A have a few questions for the experts. Any help is greatly appreciated. I’m using the classic version of Phoenix NLME 1. Is it a good practice to use your PK estimates as link paramters for you PK-PD model? 1. What are the best criteria for evaluating a linked model? 2. I’m getting results from my linked model, but should I be concerned if the core ouput also contains the warning “Input units do not allow for conversion” for most subjects? Is this likley due to the fact I’m using beats per min (bpm) as units for my heart rate effect data? Should this instead be represented as a % of the baseline values? 4. Is there a way to obtain the mean, median, range, etc., for all secondary and final parameters between all six subjects? Thank you Marc R.