PK-PD model of Binary repsonse

Phoenix Certara Forums Modelling and Simulation
1

HI Folks,

Can we develop PK-PD model with binary reponse data in NLME?

If yes, sharing some more information or suggestion or any built template will be appreciated.

Thanks in advance!!

Regards,

Ygs

2

Hi Ygs, there are some worked examples listed inthe help;

https://onlinehelp.certara.com/phoenix/8.3/index.html#t=topics%2Fnlmeexamples.htm%23XREF_15153_Maximum_Likelihood

e.g. Three category multinomial model with a covariate

Simon

3

Hi Yglsla,

there are also a couple of examples in out PML School (NONMEM-NLME Comparisons):

https://support.certara.com/forums/topic/1272-pd-categorical-response/

Bernd

4

Thank you Simon and Bernd for information and suggestions.

Thanks.. :slight_smile:

Regards,

Ygs

5

note that phoenix has lot of flexibility and you have multi, ordinal :

https://onlinehelp.certara.com/phoenix/8.2/index.html?#t=topics%2Fobservationssyntax.htm&rhsearch=multi%20ordinal&rhhlterm=multi%20ordinal&rhsyns=%20

binary 0/1 is a special case of more general 0/1/2,… models

when using multi or ordinal you will have automatic simulation and vpc

you can also write your LL + simulate statement to do whatever you need