PK-PD model of Binary repsonse

HI Folks,

Can we develop PK-PD model with binary reponse data in NLME?

If yes, sharing some more information or suggestion or any built template will be appreciated.

Thanks in advance!!

Regards,

Ygs

Hi Ygs, there are some worked examples listed inthe help;

https://onlinehelp.certara.com/phoenix/8.3/index.html#t=topics%2Fnlmeexamples.htm%23XREF_15153_Maximum_Likelihood

e.g. Three category multinomial model with a covariate

Simon

Hi Yglsla,

there are also a couple of examples in out PML School (NONMEM-NLME Comparisons):

https://support.certara.com/forums/topic/1272-pd-categorical-response/

Bernd

Thank you Simon and Bernd for information and suggestions.

Thanks.. :slight_smile:

Regards,

Ygs

note that phoenix has lot of flexibility and you have multi, ordinal :

https://onlinehelp.certara.com/phoenix/8.2/index.html?#t=topics%2Fobservationssyntax.htm&rhsearch=multi%20ordinal&rhhlterm=multi%20ordinal&rhsyns=%20

binary 0/1 is a special case of more general 0/1/2,… models

when using multi or ordinal you will have automatic simulation and vpc

you can also write your LL + simulate statement to do whatever you need