Nonlinear Clearance
October 6, 2016 | 10am EST
Presenter: Dan Weiner
https://support.certara.com/forums/topic/916-intro-to-pml-school-and-lesson-1-on-nonlinear-clearance/?p=3921
Metabolite Kinetics
Simultaneously model plasma data of a drug and a metabolite following 5-minute infusion. Metabolite clearance follows Michaelis-Menten kinetics
October 20, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/928-lesson-2-parent-and-metabolite-kinetics/?p=3986
Two-compartment Repeated Oral Dosing
Fit multiple dose kinetic and dynamic data sequentially
November 3, 2016 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/939-lesson-3-two-compartment-repeated-dosing/?p=4051
Nonlinear Kinetics
Fit nonlinear clearance for a highly plasma-bound compound using Michaelis-Menten elimination for two subjects with different Km
November 17, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/954-lesson-4-multiple-absorption-routes-via-graphical-model-builder/?p=4188
Simultaneous Fitting of IV/PO Data
Fit IV data first then IV and PO data separately and simultaneously
December 1, 2016 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/961-lesson-5-simultaneous-fitting-of-plasma-and-urine-data/?p=4229
Target-Mediated Drug Disposition
Model circulating plasma target with a TMDD model
December 15, 2016 | 10am EST
Presenter: Dan Weiner
https://support.certara.com/forums/topic/967-lesson-6-target-mediated-drug-disposition/?p=4250
Enterohepatic Recirculation
Model enterohepatic recirculation (EHC) after intravenous administration
January 19, 2017 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/990-lesson-7-enterohepatic-recirculation/?p=4340
One-compartment 1st and 0-order Input
Fit and discriminate between first and zero-order absorption models
February 2, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1000-lesson-8-one-compartment-1st-and-0-order-input/?p=4365
Allometry-Elementary/Complex Dedrick Plot
Simultaneously fit an allometric model to data from mouse, rat and man
February 16, 2017 | 10am EST
Presenter: Dan Weiner
https://support.certara.com/forums/topic/1013-lesson-9-allometric-scaling/?p=4412
Turnover III: Nonlinear Disposition
Characterize turnover of an endogenous compound
March 2, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1017-lesson-10-turnover-iii-nonlinear-disposition/?p=4432
Analysis and Comparison of Link, Turnover and Receptor Binding Models
Fit a link-, turnover- and receptor binding model to data
March 16, 2017 | 10am EST
Presenter: Dan Weiner
https://support.certara.com/forums/topic/1026-lesson-11-analysis-and-comparison-of-link-turnover-and-receptor-binding-model/?p=4463
Sigmoidal Concentration-response Models
Apply Gompertz, Weibull, Richards, Morgan-Mercer-Flodin, Hill and logistic models
March 30, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1033-lesson-12-sigmoidal-concentration-response-models/?p=4488
Analysis of a Tissue Growth/Kill Model
Analyze a tumor cell kill model after acute dosing
April 13, 2017 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/1040-lesson-13-modeling-tumor-growthkill/?p=4499
Modeling Inhibition of Enzyme Activity by Means of Turnover
Construction of a mechanistic turnover model
April 27, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1045-lesson-14-modeling-enzyme-inhibition-by-means-of-turnover/?p=4508
Effect Compartment III: IV infusion
Model response-time data with a link-model
May 11, 2017 | 10am EST
Presenter: Dan Weiner
https://support.certara.com/forums/topic/1050-lesson-15-effect-compartment-iii-iv-infusion/?p=4516
Turnover Model 1: IV Bolus Dosing
Model Warfarin-PCA interaction
June 8, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1063-lesson-16-warfarin-iv-bolus-turnover-model/?p=4561
Turnover Model 4: IV Infusions
Apply a turnover model to multiple IV dosing response data
June 22, 2017 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/1067-lesson-17-turnover-model-iv-iv-infusion/?p=4573
Turnover Model 1: Repeated Dosing I
Apply a turnover model to repeated po dosing response data
July 13, 2017 | 10am EST
Presenter: Chris Mehl
https://support.certara.com/forums/topic/1078-lesson-18-turnover-models-with-repeated-dosing/?p=4611
Dose-response-time Analysis I-IV
Analyze dose-response-time data with an instantenous effect model
July 27, 2017 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/1089-lesson-19-dose-response-time-analysis/?p=4656
Transduction Modeling: Assessment of Number of Transit Compartments
Analyze a transduction rate limited response time course
August 10, 2017 | 10am EST
Presenter: Bernd Wendt
https://support.certara.com/forums/topic/1095-lesson-20-transduction-modeling/?p=4679
Minimal physiologically-based pharmacokinetic model for monoclonal antibodies
November 16 | 10 am EST
Presenter: Loan Pharm (Camargo)
https://support.certara.com/forums/topic/1116-minimal-physiologically-based-pharmacokinetic-model-for-monoclonal-antibodies/?p=4875
Target-mediated Drug Disposition (TMDD) modeling using the Quasi-equilibrium assumption
November 30 |10 am EST
Presenter: Frank Striebel (Morphosys)
https://support.certara.com/forums/topic/1120-target-mediated-drug-disposition-tmdd-modeling-using-the-quasi-equilibrium-assumption/?p=4896
Adaptive Simulations: extending PML to trial simulations
December 14 | 10 am EST
Presenter: Bernd Wendt (Certara)
https://support.certara.com/forums/topic/1125-adaptive-simulations-extending-pml-to-trial-simulations/?p=4909
