Hello Serge/ experts
We are trying to predict the tumor concentrations from plasma data based on the paper attached, we have tried to fit using the mittyright code in the attached PHX PRJ file.
We are also attaching the hypothetical model we are looking at is also attached.
Please help us in correcting the code and predicting the tumor concentrations
Awaiting some reply
Regards
HKK
PML Learning.phxproj (735 KB)
26074-72685-1-PB.pdf (1.09 MB)Dear Harishkk,
the hypothetical model at attached picture is not the same as in the article. What is your goal?
there’s bidirectional arrow between vascular and intersticial compartments of tumor in the article.
there’s a timelag for drug input into the vascular system of tumor in the article
The steps to predict concentrations could be the following:
build a separate model to get the values of parameters for PK part using the data you sent (2-compartment micro model)
import the values of parameters of PK model (k12, k21, ke) to the main model (in the article the PK part is presented as a biexponential macro model, so just substitute it)
run model in simulation mode
Profit!
BR,
Mittyright
