Q: Can you set different PK parameters for individual subjects and then do PD fits with a population model?
A: Yes, this was shown as part of the demo in the webinar. Please download the materials and look at the object: Built_in_Model_pop. The steps that you need to perform are:
- use CL and V as covariates [attachment=3287:covariate1.png]
- call them CLind and Vind [attachment=3288:covariate2.png]
- switch to Graphical Editing Mode and insert 2 procedures:
- Proc1: Ke = CLind/Vind [attachment=3289:proc1.png]
- Proc2: V = Vind [attachment=3290:proc2.png]
- In graphical editing mode
- connect Ke from Proc1 with Ke in the flow between central and elimination compartment
- connect V from Proc2 with V in central compartment
- The resulting model should look like this:
