Problem: What dose would give me an X plasma concentration 2 hours after dosing of a 0.5 hour infusion?
I would like to set the dose as a variable to find the dose that would give a specific plasma concentration after 2 hours. The plasma concentration I would put in a dummy sheet after 2 hours. The dosing is an IV infusion with a duration of 0.5 hours.
If I define A1Dose as a variable an error of 2 definitions for the variable appears “Variable ‘A1Dose’ multiple definition”.
The sequence statement would be an easy fix for a bolus dose but not since this an infusion.
Anyone got a solution for this?
My model (as an example):
deriv(A1 = - (A1 * ke)
C=A1/V
error(CEps = 0.25)
observe(CObs = C * (1 + CEps))
dosepoint(A1, idosevar = A1Dose, infdosevar = A1InfDose, infratevar = A1InfRate)
stparm(ke=tvke)
stparm(V = tvV)
fixef(tvke (freeze) = c(0, 1, ))
fixef(tvV (freeze) = c(0, 1, ))