Is it possible to fit simultaneously SC and IV data, using different models depending on the route of administration but sharing a subset of model parameters? (A similar problem is described here: http://learnpkpd.com/2011/01/09/using-nonmem-to-fit-iv-and-oral-data-simultaneously/))
[quote=“Igor Vostiar, username:ivostiar”]
Is it possible to fit simultaneously SC and IV data, using different models depending on the route of administration but sharing a subset of model parameters? (A similar problem is described here: http://learnpkpd.com/2011/01/09/using-nonmem-to-fit-iv-and-oral-data-simultaneously/))
Dear Igor
The answer is Yes and I made an example for you. I hope I understood the question right.
In the attached project (14 version, second model), 50 patients follow a one compartment model with IV dosing and 50 patients follow a 2 compt model with extravascular input.
We assume they share V and Cl. The bioavailability is 50% (ilogit0).
You can share model parameters by defining these shard parameters (see graph in the model) and linking them to the V and Cl of both models.
I hope it helps. If something not clear or the question was different, please let me know.
best Regards
Serge
[/quote]IV_ORAL_different_models.phxproj (975 KB)
Dear Serge,
Thank you for for a prompt reply, this is exactly what I am looking for. The only problem I have at the moment is how to open the project file, my system is Build 6.3.0.395 and it has difficulties to open the project file..
Here we go. I translated into13. please upgrade to 14 ASAP. The 13 version is really out dated and you should not use it.
Best Regards
Serge
version13_iv_oral_2_diff_models_shared_parameters.phxproj (754 KB)
Hi Igor, also don’t foget to use the search function; e.g. ‘simultaneous’ there are several related threads on here already;
http://www.certara.com/forums/topic/528-simultaneous-iv-and-po-2-cpmt-model/?hl=simultaneous
http://www.certara.com/forums/topic/604-simultaneous-iv-and-extravascular-sd-and-rd/?hl=simultaneous
Simon