Hi. Is there a way to model two phases of a crossover study simultaneously? In one phase, subjects received a CYP3A inhibitor, in another phase, they did not. I am currently modeling simultaneously by assigning an arbitrary time separation of 100 hours, but ideally, I would like to use a flag variable (0 or 1) to model the data. Please let me know how you would do this, not only in coding but also in the dataset. Thanks! Cathrine.
An NLME crossover example is attached. Note that you can either put the actual times (even if they are weeks apart) or use a reset (column called reset, set to 1 when concentrations are supposed to be zero again, 0 otherwise. Then check “Reset” input option on input options tab, but first deselect “Sort Input” in Run Options.). [file name=Xover.phxproj size=6988579]/extranet/media/kunena/attachments/legacy/files/Xover.phxproj[/file]Xover.phxproj (6.66 MB)
A different version of the same project is attached, except it has a model with a Reset in it in addition to the one without the Reset. [file name=Xover-20120620.phxproj size=3156850]/extranet/media/kunena/attachments/legacy/files/Xover-20120620.phxproj[/file]
Xover-20120620.phxproj (3.01 MB)