Here is the PML model text for a target mediated drug disposition model. test(){ DOSE = 2.7 deriv(CMAB = -CMABKelmAb - KonCMAB*(CAg - CComplex) + KoffCComplex) error(CMABEps=1) observe(CMABObs = CMAB+CMABEps) deriv(CComplex = Kon(CAg - CComplex)CMAB - (Koff + KelAbAg)CComplex) deriv(CAg = Ksyn - KelAbAgCComplex - KelAg(CAg - CComplex)) Ksyn = KelAg*CAg0 PctRO = (1-((CAg - CComplex)/CAg0))*100 sequence{ CComplex = 0; CMAB = DOSE/Vc; CAg = CAg0; } stparm(Vc = tvVc) stparm(KelmAb = tvKelmAb) stparm(KelAbAg = tvKelAbAg) stparm(Kon = tvKon) stparm(Koff = tvKoff) stparm(KelAg = tvKelAg) stparm(CAg0 = tvCAg0) fixef(tvVc = c(, 4, )) fixef(tvKelmAb = c(, 0.025, )) fixef(tvKelAbAg = c(, 0.02, )) fixef(tvKon = c(, 1, )) fixef(tvKoff = c(, 1, )) fixef(tvKelAg = c(, 0.7, )) fixef(tvCAg0 = c(, 4.5, )) }