Use of CD from book:Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts & Applications

Phoenix Certara Forums Modelling and Simulation
1

Hi

We purchased book entitled" Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts & Applications"( The 4th edition by Gabrielsson and Weiner)"

This book enclosed CD with all exercises and WinNonlin model/ command files.

Please guide us how to use example file from CD (WinNonlin 5 mode) in Phoenix WinNonlin 6.3

Best Regards,

Vallabh mahajan

2

Hi Vallabh, you’ll may well need to run the 32 bit version of Phoenix to import some of those files, take a look at the relevant section, p15, in the Phoenix 1.4 Getting Started Guide.pdf and perhaps try one of the examples from;

C:\Program Files (x86)\Pharsight\Phoenix\application\Examples\Legacy WinNonlin

You will be wanting to use the “WNL 5 ascii format” option under the “WNL5 classic modeling tab”, if you have a problem simply paste the project here with reference to the one you’re trying to replicate and we can advise further.

Bear in mind this format is essentially obsolete but if you want to create the same model in PML it shouldn’t be too hard, there are already several examples on the forum. Normally the code is much simpler than the original.

Simon.

3

Also note than Johan Gabrielsson & I are working on a 5th ed of the book which hopefully will be released before the end of this year (or early next year). This new edition will include all examples in PHX format.

Dan Weiner

4

Dear All,

Thanks for kind reply and i would like to thanks certara support.

I got help for certara support, please see below mentioned path to access WNL files

Phoenix platform version 1.3 installs 2 executables: 1) a 64-bit executable named “Phoenix.exe” and 2) a 32-bit executable named “Phoenix32.exe”

In order to use files from legacy WinNonlin 4.x or 5.x, you must run the 32-bit version of Phoenix named “Phoenix32.exe”. To do this, one must first create a New Project in Phoenix. Then, use File | Import to import the legacy WinNonlin file(s) of interest. Please refer to the steps below:

  1. Select Start → Programs → Pharsight → Phoenix → Phoenix32
    (see attached screenshot)

  2. Select File | New Project

  3. Select File | Import

  4. Browse for the WinNonlin 4.x or 5.x files of interest, and then click Open.

  5. An import preview screen will guide you through the import process, for example how to handle column headers and units from a spreadsheet. Click Next >> as many times as required and then click Finish.

Any WinNonlin files of the format *.pwo, *.pmo, *.pco, *.pto, and *.wsp can be imported into a Phoenix project. Additional details about importing files can be found in the Phoenix application using Help | Contents | Phoenix Basics | Phoenix Functions | Importing data sets.

Best Regards,

Vallabh mahajan

5

Couple of people asked me about getting hold of a copy of the 5th Edition recently, I found buying direct from the publishers cheaper.

https://books.apotekarsocieteten.se/en/pharmacokinetic-pharmacodynamic-data-analysis-concepts-and-applications-ed-5-eng

https://www.amazon.co.uk/Pharmacokinetic-Pharmacodynamic-Data-Analysis-Applications/dp/9198299107

Simon