using Crossover for Tmax test

Phoenix Certara Forums Phoenix WNL basics
1

Dear all，

When using Crossover for Tmax testing, how can I judge whether it is equivalent by the result?

I read the “The nonparametric methods proposed by Koch (1972)” document, and I think he is doing the following steps to judge:

  1. Determine if the P value of the sequence is greater than 0.05,

  2. If the P value of the sequence is less than 0.05, the test of “Treatment” cannot be performed.

  3. If the P value of the sequence is greater than 0.05, it is judged whether the P value of the treatment is greater than 0.05.

  4. If the P value of the Treatment is greater than the equivalent, otherwise it is not equivalent.

  5. If the P value of the sequence and the P value of the Period are both greater than 0.05, a sign test can be used instead of the rank sum test used in the above steps.

Assuming α = 0.05, all of the above P values are the results in the “Effects” table.

Is the above judgment process correct?
If not, what is the correct judgment process?

Best，

0521

2

Dear 0521,

Please refer to the link below, and there is a detail explanation bu Helmut.

https://support.certara.com/forums/topic/730-tmax-statistical-comparison-crossover-design/

https://forum.bebac.at/mix_entry.php?id=14840&page=0&category=0&order=last_answer&descasc=DESC#p14841

Best,

Chandramouli