Hi there, I have a project that I am trying to make VPCs . The treatment covariate is on only half of the plasma concentrations (there was a treatment applied halfway through the administration protocol that affected V and CL). However, when I go to make a Sim/Pred Check and run it, the treatment effect is reset to 0 and of course the curve is no longer following the points. I have another treatment that has no affect CL and V and this one (with no covariate) is easily done. Thoughts? Andrea
In order to do VPC by strata, you need to know for each individual the treatment they were on. Can you explain what d you mean by"The treatment covariate is on only half of the plasma concentrations"? Do you mean half of the concentrations data do not have treatment information?
Thanks
Serge