Allometric scaling using FFM

Phoenix Certara Forums Modelling and Simulation
1

Hi,

I want to use FFM instead of body weight for allometric scaling, but I’m not sure if setting the impact to 1 for VD and 0.75 for CL is correct with FFM.

Aslo, can we still use body weight as a covariate after implementing the FFM effect?

Thanks

2

https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14202please look at this publication.

you can still look at other size covariates to see if there is any residual effects

3

Thanks for your answer, Sameer !!

The study is very interesting and helpful to clarify the concept.