Combined transit compartment model and first-order absorption

Phoenix Certara Forums Modelling and Simulation
1

Dear All,

I am trying to implement the NONMEM model code shown in the supplement section of the below publication into Phoenix NLME without success:

http://synapse.koreamed.org/Synapse/Data/PDFData/1179TCP/tcp-23-66.pdf

Could anyone help convert this into NLME code, and/or share code of a transit compartment with estimation of the number of transit compartments?

Kind regards,

Pau

2

Dear Pau

I am attaching a project I made that takes advantage of our unique transit statement. To make sure fraction is between 0 and 1, I used the inverse logit function(ilogit).

I recreated similar conditions than in the paper. The advantage is that if you simulate data , you can fit the model to these data and optimize the number of transit compartments nd it will work with both single and multiple doses.

Let me know if all is clear. Look at the pml user guide for the syntax.

Looking forward hearing from you.

best Regards

Serge

transit_special.phxproj (166 KB)

3

I updated the project just in case the one I sent just before would not work. Click on initial estimates and you will see the impact of both ktr and ntr.

Best

Serge

transit_special.phxproj (165 KB)