The phoenix WinNonlin 8.3 provided VIF based study-design example (study-design project attached).
I am wondering how the initial estimates V_F=10, K01=3, K10=0.05 generated because non one of initial estimates from PK or ML model generated such results (Pk model project attached)
Please see details in the attached study-design question.
Thanks
DV
PK_Model.phxproj (636 KB)Study_Design.phxproj (223 KB)study_design question.docx (119 KB)