Hi, Could someone please give me a short run on pk modeling with Phoenix Model in Phoenix 1.3 (or earlier version). I have experience in using the classic WNL PK modeling option (been a academic and industrial user since version 3.) but I am new to the Phoenix model routine. The question I have is how to generate the model parameters (Ka, Vd, Kel etc) output in Phoenix Model? I checked all the output and I don’t see primary/secondary parameter output that resemble the classic WNL modeling output. Thanks John
Hi John, Did you work through the examples guides in C:\Program Files (x86)\Pharsight\Phoenix\docs - actually the NLME examples guide is really handy for learning about writing your own models even if you don’t have the NLME license enabled. Where exactly are you getting stuck? I assume you’ve sent your data to a Phoenix model and you have some candidate e.g. 1 or 2 compartment etc in mind? If so a simple way to get your first models is to use the “set WNL” model button; 
and choose the equivalent model, (use PK/Emax drop down to get PkPD link models); 
Then map your inputs and dose info (the warnings tab on the far right should help here). 
now you’re ready to set up your initial estimates (there is no automatic curve stripping option like WNL classic.) - look at this tab and once you have something approximate and have clicked all the arrows grey click execute. 
You should now be brought to the results and your final estimates are in the table THETA; the prefix tv stands for typical value and is redundant in individual modelling. 
I hope that helps, probably one of our training courses would really help you get more from the software, where are you based we hold courses worldwide either public or at your site; Certara | Drug Development Solutions Simon
Thanks Simon, Your message was really helpful. One question though, can I use the graphical method to do pk modeling? Thanks John
of course, built-in, graphical and text are all interchangeable forms of the same model. Simon.