I am working with a dietary supplement that increases the systemic amount of several amino acids (aa) above baseline values. The analysis requires estimation of incremental AUC (AUCi) and net incremental AUC (net AUCi). I have a baseline value for the aa only, there is no threshold value. The drug effect (model 220) option in NCA allows the input of a baseline value and provides as output the parameters outlined below
AUC_Above_B
Area under the response curve that is above the baseline (dark gray areas in the above diagram).
AUC_Below_B
Area that is below the baseline and above the response curve (combined blue and pink areas in the above diagram).
Is AUC Above B equivalent to AUCi? Can net AUCi be estimated as
[AUCabove B] - [AUC below B]? See Figure 11 (c & e) in the attached paper discussing glycemic index for reference of what I am looking to estimate.
Glycemic_index_methodology.pdf (559 KB)