Input file error

Phoenix Certara Forums Modelling and Simulation
1

We imported in vivo data for our project.

Tried fitting it to a compartmental model using Phoenix model object.

  • Population PK

  • Run mode: simple

Two problems faced:

  1. Initial estimates tab doesn’t show observed points for optimization

  2. On run, the error panel displays: Error reading file …..\phoenix\DME…0001.txt. File does not exist.

What we tried:

  1. Making a new input file

  2. Using phoenix worksheet

  3. Modifying a different input file that was used in another project

Kindly help sort this error. Urgent!

Thank you

2

unless I can reproduce on my end then it is very unlikely I can help. did you share the project with support or can you copy paste here the model code and first few subjects of your data input file ?

3

Hi,

Here is my code,

test(){
deriv(Aa = - Ka * Aa)
deriv(A1 = Ka * Aa - Cl * C - Cl2 * (C - C2))
deriv(A2 = Cl2 * (C - C2))
dosepoint(Aa, tlag = Tlag)
C = A1 / V
C2 = A2 / V2
error(CEps = 0.1)
observe(CObs = C * exp(CEps))
stparm(Ka = tvKa * exp(nKa))
stparm(V = tvV * exp(nV))
stparm(V2 = tvV2 * exp(nV2))
stparm(Cl = tvCl * exp(nCl))
stparm(Cl2 = tvCl2 * exp(nCl2))
stparm(Tlag = tvTlag * exp(nTlag))
fixef(tvKa = c(, 0.21, ))
fixef(tvV = c(, 500, ))
fixef(tvV2 = c(, 16, ))
fixef(tvCl = c(, 31, ))
fixef(tvCl2 = c(, 3, ))
fixef(tvTlag = c(, 0.1, ))
ranef(diag(nV, nCl, nKa, nV2, nCl2, nTlag) = c(1, 1, 1, 1, 1, 1))
}

Dose: 500 mg

invivo input.xlsx (9.86 KB)

Thanks.

4

how do you map your dose data and lenght of infusion of 12 h ?

5

It is an extravascular 2 compartment model so there is no length of infusion.

And dose is mapped using internal worksheet in dosing option.

6

all works not sure what is wrong on your end

helpforum.phxproj (1.21 MB)

7

I agree with Samer and suggest you email support_AT_certara,com to resolve your installation issue. Have you ever ran a phoenix model successfully with this installation?

If not then you need to check that you are installing the GCC compiler, which although optional for classic WNL functions is mandatory for Phoenix models. Simon.

8

Thanks for your support. Will get back to you if any issue persists.