Lesson 10: Turnover III - Nonlinear Disposition

Phoenix Certara Forums PML School
1

On March, 2nd we presented a turnover model of an endogenous compound with saturated elimination. We explained how to setup a highly variable multiple dosing scheme in Phoenix WinNonlin.Finally, we compared the results with a simple linear elimination model.

Here are the materials:

Textual Model file:

PK32_model.txt (843 Bytes)

Slide Deck:

PK32_slides.pdf (747 KB)

Link to the recording of the webinar:

https://certara.webex.com/certara/lsr.php?RCID=88633e0da6ef0404c8ce887f7819d30a

Bernd

PK32_model_2.txt (837 Bytes)

2

There was a flaw in the textual model that we posted:

secondary parameters were not using the typical values of the primary parameters from which they were derived.

This has been corrected in the new version that you can download from here:

PK32_model_2.txt (837 Bytes)

Bernd